CD47 Protein (CD47)

Catalog No. ABIN7321030

Recombinant CD47 protein expressed in Human Cells.

Quick Overview for CD47 Protein (CD47) (ABIN7321030)

Target: CD47

Protein Type: Recombinant

Origin: Rhesus Monkey

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Rhesus Macaque CD47/IAP/OA3 (N-6His-Flag)

Sequence: Gln19-Glu141

Characteristics: Recombinant Rhesus macaque Leukocyte Surface Antigen CD47 is produced by our Mammalian expression system and the target gene encoding Gln19-Glu141 is expressed with a 6His, Flag tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Comment:

33-55 kDa

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD47

Alternative Name: CD47/IAP/OA3

Background:

Background: CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig-like domain, five membrane-spanning regions with short intervening loops, and C-terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA, it binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cellcell adhesion, it enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. It may play a role in membrane transport and/or integrin dependent signal transduction. It also prevents premature elimination of red blood cells.

Synonym: Leukocyte Surface Antigen CD47, Antigenic Surface Determinant Protein OA3, Integrin-Associated Protein, IAP, Protein MER6, CD47, MER6

Molecular Weight: 15.7 kDa

UniProt: F7A802