Quick Overview for DDR2 Protein (His tag) (ABIN7321116)
Target
See all DDR2 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This DDR2 protein is labelled with His tag.
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Purpose
- Recombinant Rat DDR2 Kinase/CD167b Protein (His Tag)
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Sequence
- Met1-Arg399
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Characteristics
- A DNA sequence encoding the rat DDR2 (B1WC09) (Met1-Arg399) was expressed with a polyhistidine tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method
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Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) protein (His tag)
DDR2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) protein (His tag)DDR2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 1-855) protein (GST tag)DDR2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (Active) protein (GST tag,His tag)DDR2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) protein (His tag)DDR2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (Active) protein (His tag)DDR2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (Active) protein (Fc Tag)DDR2 Origin: Rat Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE Active
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Comment
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58 kDa
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
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Alternative Name
- DDR2
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Background
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Background: Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: DDR2
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Molecular Weight
- 43.9 kDa
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UniProt
- B1WC09
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Pathways
- RTK Signaling
Target
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