TNNC1 Protein
Quick Overview for TNNC1 Protein (ABIN7317698)
Target
See all TNNC1 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human Troponin C/TNNC1 Protein
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Sequence
- Met 1-Glu161
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Characteristics
- A DNA sequence encoding the human TNNC1 (NP_003271.1) (Met1-Glu161) was expressed and purified.
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Endotoxin Level
- Please contact us for more information.
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Comment
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20 kDa
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 150 mM NaCl, 10 mM Na2HPO4, pH 7.5
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- TNNC1 (Cardiac Troponin C (TNNC1))
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Alternative Name
- TNNC1
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Background
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Background: Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle.
Synonym: CMD1Z,CMH13,TN-C,TNC,TNNC
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Molecular Weight
- 18.4 kDa
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NCBI Accession
- NP_003271
Target
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