OLR1 Protein (AA 60-363) (His tag)

Catalog No. ABIN7275198

This Recombinant OLR1 protein is produced in HEK-293 Cells.

Quick Overview for OLR1 Protein (AA 60-363) (His tag) (ABIN7275198)

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 60-363

Purification tag / Conjugate: This OLR1 protein is labelled with His tag.

Purpose: Mouse LOX1 Protein

Sequence: Arg60-Ile363

Characteristics: Recombinant Mouse LOX1 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Arg60-Ile363.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Mouse LOX1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Mouse LOX1 is greater than 95% as determined by SEC-HPLC.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Alternative Name: LOX1

Background: LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.

Molecular Weight: 36.1 kDa. Due to glycosylation, the protein migrates to 55-63 kDa based on Bis-Tris PAGE result.

UniProt: Q9EQ09