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OLR1 Protein (His tag)

OLR1 Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Catalog No. ABIN7321158
  • Target See all OLR1 Proteins
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Protein Type
    Recombinant
    Origin
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    Rat
    Source
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This OLR1 protein is labelled with His tag.
    Purpose
    Recombinant Rat OLR1/LOX1 Protein (His Tag)
    Sequence
    Leu60-Gln364
    Characteristics
    A DNA sequence encoding the rat OLR1 (O70156) (Leu60-Gln364) was expressed with a polyhistidine tag at the N-terminus.
    Purity
    > 90 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product OLR1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Alternative Name
    OLR1/LOX1 (OLR1 Products)
    Synonyms
    OLR1 Protein, LOX1 Protein, Olr1 Protein, CLEC8A Protein, LOXIN Protein, SCARE1 Protein, SLOX1 Protein, LOX-1 Protein, SR-EI Protein, Scare1 Protein, Oldlr1 Protein, Oldr1 Protein, PLOX-1 Protein, oxidized low density lipoprotein receptor 1 Protein, oxidized low density lipoprotein (lectin-like) receptor 1 Protein, OLR1 Protein, Olr1 Protein
    Background

    Background: Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions. 

    Synonym: OLR1;Lox1;Oldlr1

    Molecular Weight
    37.9 kDa
    UniProt
    O70156
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