NRP2 Protein (AA 23-859) (His tag)

Catalog No. ABIN7275370

This Recombinant NRP2 protein is expressed in HEK-293 Cells.

Quick Overview for NRP2 Protein (AA 23-859) (His tag) (ABIN7275370)

Target: NRP2 (Neuropilin 2 (NRP2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 23-859

Purification tag / Conjugate: This NRP2 protein is labelled with His tag.

Purpose: Human Neuropilin-2 Protein

Sequence: Gln23-Pro859

Characteristics: Recombinant Human Neuropilin-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln23-Pro859.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Human Neuropilin-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Human Neuropilin-2 is greater than 95% as determined by SEC-HPLC.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: NRP2 (Neuropilin 2 (NRP2))

Alternative Name: Neuropilin-2

Background: Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells.

Molecular Weight: 95.4 kDa. Due to glycosylation, the protein migrates to 110-115 kDa based on Bis-Tris PAGE result.

NCBI Accession: NP_003863

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals