IL-13 Protein (AA 21-132)
Quick Overview for IL-13 Protein (AA 21-132) (ABIN7454149)
Target
See all IL-13 (IL13) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 21-132
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Purpose
- Human IL-13 Protein
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Sequence
- Gly21-Asn132
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Characteristics
- Recombinant Human IL-13 Protein is expressed from HEK293 without tag.It contains Gly21-Asn132.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Human IL-13, No Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-13 Ra 2, hFc Tag with the EC50 of 2.84μg/ml determined by ELISA. See testing image for detail.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- IL-13 (IL13) (Interleukin 13 (IL13))
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Alternative Name
- IL-13
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Background
- Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (By similarity).
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Molecular Weight
- 12.35 kDa. Due to glycosylation, the protein migrates to 20-45 kDa based on Tris-Bis PAGE result.
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Pathways
- JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
Target
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