HAVCR1 Protein (AA 23-342) (His tag)

Catalog No. ABIN7454163

Recombinant HAVCR1 protein expressed in HEK-293 Cells.

Quick Overview for HAVCR1 Protein (AA 23-342) (His tag) (ABIN7454163)

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Cynomolgus

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 23-342

Purification tag / Conjugate: This HAVCR1 protein is labelled with His tag.

Purpose: Cynomolgus TIM-1/HAVCR1 Protein

Sequence: Val23-Gly342

Characteristics: Recombinant Cynomolgus TIM-1/HAVCR1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val23-Gly342.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Cynomolgus TIM-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Cynomolgus TIM-1 is greater than 95% as determined by SEC-HPLC.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Alternative Name: TIM-1

Background: Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation.

Molecular Weight: 35.25 kDa. Due to glycosylation, the protein migrates to 100-150 kDa based on Bis-Tris PAGE result.

UniProt: A0A2K5WXJ6