CCL26 Protein
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- Target See all CCL26 Proteins
- CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human C-C Motif Chemokine 26 is produced by our E.coli expression system and the target gene encoding Ser27-Leu94 is expressed.
- Characteristics
- Extracellular Domain Protein
- Purity
- Greater than 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CCL26 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Storage
- -20 °C
- Storage Comment
- Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))
- Alternative Name
- CCL26 (CCL26 Products)
- Synonyms
- CCL26 Protein, IMAC Protein, MIP-4a Protein, MIP-4alpha Protein, SCYA26 Protein, TSC-1 Protein, Ccl26l Protein, C-C motif chemokine ligand 26 Protein, chemokine (C-C motif) ligand 26 Protein, CCL26 Protein, Ccl26 Protein
- Background
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C-C Motif Chemokine 26, CC Chemokine IMAC, Eotaxin-3, Macrophage Inflammatory Protein 4-Alpha, MIP-4-Alpha, Small-Inducible Cytokine A26, Thymic Stroma Chemokine-1, TSC-1, CCL26, SCYA26
Description: Chemokine (C C Motif) Ligand 26 (CCL26) is a novel small cytokine belonging to the CC chemokine family, which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for Eotaxin-3 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant Eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, Eotaxin-3 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7. - Molecular Weight
- 8.21 KDa
- UniProt
- Q9Y258
- Pathways
- Regulation of Actin Filament Polymerization
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