Oncostatin M Protein (OSM) (His tag)

Catalog No. ABIN7455625

This Recombinant Oncostatin M protein is produced in Escherichia coli (E. coli).

Quick Overview for Oncostatin M Protein (OSM) (His tag) (ABIN7455625)

Target: Oncostatin M (OSM)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: Greater than 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Oncostatin M protein is labelled with His tag.

Purpose: Recombinant Human Oncostatin M is produced by our E.coli expression system and the target gene encoding Ala26-Arg221 is expressed with a 6His tag at the N-terminus.

Characteristics: Extracellular Domain Protein

Purification: Affinity purification

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mMTris-HCl, 1 mM EDTA, 200 mM NaCl, pH 7.5.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Oncostatin M (OSM)

Alternative Name: OSM

Background: Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological activities through specific cell surface receptors. The low affinity LIF receptor that shares the similarity of containing protein gp130 has now been identified to be a component of a high- affinity OSM receptor that will transduce OSM signals. OSM has also been shown to play a role in both pro and anti-inflammatory actions. OSM may also be involved in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development.

Molecular Weight: 24.44 KDa

UniProt: P13725

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion