IL20RB Protein (Fc Tag)

Catalog No. ABIN7455661

This Recombinant IL20RB protein is produced in HEK-293 Cells.

Quick Overview for IL20RB Protein (Fc Tag) (ABIN7455661)

Target: IL20RB (Interleukin 20 Receptor beta (IL20RB))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Purity: Greater than 85 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This IL20RB protein is labelled with Fc Tag.

Purpose: Recombinant Human Interleukin-20 Receptor Subunit Beta/IL-20RB is produced by our Mammalian expression system and the target gene encoding Asp30-Ala230 is expressed with a Fc tag at the C-terminus.

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Storage: -80 °C

Storage Comment: Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: IL20RB (Interleukin 20 Receptor beta (IL20RB))

Alternative Name: IL-20RB

Background: Interleukin-20 receptor subunit beta,IL-20 receptor subunit beta,IL-20R-beta,IL-20RB,IL-20R2,DIRS1,hCG_2022374,FNDC6,MGC34923,fibronectin type III domain containing 6,interleukin-20 receptor II
Interleukin-20 receptor subunit beta(IL20RB) is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons, cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.

Molecular Weight: 49.6 KDa

UniProt: Q6UXL0

Pathways: Regulation of Leukocyte Mediated Immunity