GDNF Protein
Quick Overview for GDNF Protein (ABIN7488782)
Target
See all GDNF ProteinsProtein Type
Origin
Source
Purity
Grade
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Purpose
- Human GDNF / ATF / hGDNF Protein, premium grade
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Sequence
- Ser 78 - Ile 211
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Characteristics
- Human GDNF Protein, premium grade is expressed from human 293 cells (HEK293). It contains AA Ser 78 - Ile 211 (Accession # P39905-1).
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Endotoxin Level
- 0.1 EU per μg
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Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein
GDNF Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein (His tag)GDNF Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein (Fc Tag)GDNF Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 1-211) protein (GST tag)GDNF Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Glial Cell Line Derived Neurotrophic Factor (GDNF) proteinGDNF Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
Glial Cell Line Derived Neurotrophic Factor (GDNF) proteinGDNF Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
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Comment
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This protein carries no "tag". () The protein has a calculated MW of 15.1 kDa. The protein migrates as 15-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
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Alternative Name
- GDNF
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Background
- Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.
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Molecular Weight
- 15.1 kDa
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Pathways
- RTK Signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration
Target
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