Tspan-8 Protein (His tag)
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- Target See all Tspan-8 (TSPAN8) Proteins
- Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Tspan-8 protein is labelled with His tag.
- Purpose
- Mouse TSPAN8 Protein, His Tag (MALS verified)
- Sequence
- Gly 106 - Asn 203
- Characteristics
- Mouse TSPAN8 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Gly 106 - Asn 203 (Accession # Q8R3G9-1).
- Purity
- 90 %
- Endotoxin Level
- 1.0 EU per μg
- Grade
- MALS verified
- Top Product
- Discover our top product TSPAN8 Protein
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Tetraspanin 8 (TSPAN8) (AA 110-205) protein (Fc Tag)
TSPAN8 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tetraspanin 8 (TSPAN8) (AA 1-237) protein (GST tag)TSPAN8 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Tetraspanin 8 (TSPAN8) (AA 110-205) protein (GST tag)TSPAN8 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
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- Comment
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This protein carries a polyhistidine tag at the N-terminus. (10xHis) The protein has a calculated MW of 12.8 kDa. The protein migrates as 15-19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))
- Alternative Name
- TSPAN8 (TSPAN8 Products)
- Synonyms
- tm4sf3 Protein, MGC64550 Protein, GB13255 Protein, TM4SF3 Protein, tetraspanin-8 Protein, tspan8 Protein, TSPAN8 Protein, CO-029 Protein, C76990 Protein, E330007O21Rik Protein, Tm4sf3 Protein, CO-29 Protein, TSPAN-8 Protein, tetraspanin 8 L homeolog Protein, tetraspanin-1 Protein, tetraspanin 8 Protein, tspan8.L Protein, LOC409511 Protein, TSPAN8 Protein, tspan8 Protein, Tspan8 Protein
- Background
- Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form 'tetraspanin webs'. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell-cell and cell-matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.
- Molecular Weight
- 12.8 kDa
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