Klotho beta Protein (KLB) (His tag)
Quick Overview for Klotho beta Protein (KLB) (His tag) (ABIN7488806)
Target
See all Klotho beta (KLB) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This Klotho beta protein is labelled with His tag.
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Purpose
- Rat Klotho beta / KLB Protein, His Tag
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Sequence
- Phe 53 - Pro 994
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Characteristics
- Rat Klotho beta, His Tag is expressed from human 293 cells (HEK293). It contains AA Phe 53 - Pro 994 (Accession # D3Z8T6-1).
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Endotoxin Level
- 1.0 EU per μg
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Klotho beta (KLB) (AA 30-983) protein (His tag)
KLB Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Klotho beta (KLB) (AA 1-1043) protein (His tag)custom-made KLB Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Klotho beta (KLB) (AA 1-1044) protein (His tag)custom-made KLB Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Klotho beta (KLB) (AA 53-994) protein (His tag)KLB Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Klotho beta (KLB) proteinKLB Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, ELISA, IP
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Comment
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This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 110.5 kDa. The protein migrates as 130-145 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- Klotho beta (KLB)
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Alternative Name
- Klotho beta
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Background
- KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.
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Molecular Weight
- 110.5 kDa
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Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Growth Factor Binding
Target
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