beta-2 Microglobulin Protein (AA 21-119) (His tag)
-
- Target See all beta-2 Microglobulin (B2M) Proteins
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 21-119
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This beta-2 Microglobulin protein is labelled with His tag.
- Sequence
- Ile21-Met119
- Characteristics
- A DNA sequence encoding the Human B2M/β2-MG (P61769-1) (Ile21-Met119) was expressed with a polyhistidine tag at the N-terminus.
- Purity
- >90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product B2M Protein
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M Origin: Rhesus Monkey, Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)B2M Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)B2M Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)B2M Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 1-119) protein (GST tag)B2M Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
-
- Target
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
- Alternative Name
- B2M (B2M Products)
- Background
-
Background: β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
Synonym: B2MG,Beta-2-Microglobulin,Beta 2 Microglobin,Beta 2 microglobulin Precursor,Beta Chain of MHC Class 1 Proteins,Beta Chain of MHC class I molecules,CDABP0092,Hdcma22p,IMD43
- Molecular Weight
- 11.73 kDa
- Pathways
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
-
