FGF3 Protein

Catalog No. ABIN7535418

This Recombinant FGF3 protein is expressed in Escherichia coli (E. coli).

Quick Overview for FGF3 Protein (ABIN7535418)

Target: FGF3 (Fibroblast Growth Factor 3 (FGF3))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % by SDS-PAGE.

Product Details

Purpose: Recombinant Human FGF-3 Protein

Sequence: DAGGRGGVYE HLGGAPRRRK LYCATKYHLQ LHPSGRVNGS LENSAYSILE ITAVEVGIVA IRGLFSGRYL AMNKRGRLYA SEHYSAECEF VERIHELGYN TYASRLYRTV SSTPGARRQP SAERLWYVSV NGKGRPRRGF KTRRTQKSSL FLPRVLDHRD HEMVRQLQSG LPRPPGKGVQ PRRRR

Specificity: Asp28-Arg212(N-Met)

Sterility: 0.22 μm filtered

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of 25 mM Tris,1M NaCl,1 mM TCEP, pH 8.0

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: FGF3 (Fibroblast Growth Factor 3 (FGF3))

Alternative Name: FGF-3

Background:

Description: Fibroblast Growth Factor 3 (FGF-3) belongs to the large FGF family which has at least 23 members. All FGF family members are heparin-binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are expressed during embryonic development and in restricted adult tissues. They act on cells of mesodermal and neuroectodermal origin to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects and tissue repair. Signaling receptors for FGFs are type I transmembrane receptor tyrosine kinases belonging to the Ig superfamily. Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. Through alternative splicing, multiple isoforms for FGF R1, 2 and 3, with distinct ligand recognition profiles, are also generated.

Name: FGF3,HBGF-3,INT2

Gene ID: 2248

UniProt: P11487

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway