RSPO1 Protein (His tag)
Quick Overview for RSPO1 Protein (His tag) (ABIN7536498)
Target
See all RSPO1 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This RSPO1 protein is labelled with His tag.
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Purpose
- Recombinant Mouse R-spondin-1/RSPO1 Protein
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Sequence
- SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCQEALYL HKGRCYPACP EGSTAANSTM ECGSPAQCEM SEWSPWGPCS KKRKLCGFRK GSEERTRRVL HAPGGDHTTC SDTKETRKCT VRRTPCPEGQ KRRKGGQGRR ENANRHPARK NSKEPRSNSR RHKGQQQPQP GTTGPLTSVG PTWAQ
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Specificity
- Ser21-Gln265
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- < 0.01EU/μg
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R-Spondin 1 (RSPO1) (AA 21-265) protein (His tag)
RSPO1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
R-Spondin 1 (RSPO1) (AA 21-146) protein (His tag)RSPO1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
R-Spondin 1 (RSPO1) (AA 21-146) protein (Fc Tag)RSPO1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
R-Spondin 1 (RSPO1) (AA 21-263) protein (His tag)RSPO1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
R-Spondin 1 (RSPO1) (Active) protein (His tag)RSPO1 Origin: Mouse Host: CHO Cells Recombinant > 95 % as determined by SDS-PAGE Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
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Concentration
- 0.47 mg/mL
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Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- RSPO1 (R-Spondin 1 (RSPO1))
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Alternative Name
- R-spondin-1/RSPO1
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Background
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Description: RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.
Name: Rspondin, R-spondin,RSPO1
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Gene ID
- 192199
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UniProt
- Q9Z132
Target
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