TSSC4 Protein (AA 1-329) (His tag)

Catalog No. ABIN7544784

Recombinant TSSC4 protein expressed in HEK-293 Cells.

Quick Overview for TSSC4 Protein (AA 1-329) (His tag) (ABIN7544784)

Target: TSSC4 (Tumor Suppressing Subtransferable Candidate 4 (TSSC4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-329

Purification tag / Conjugate: This TSSC4 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant TSSC4 Protein expressed in mammalian cells.

Sequence: MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS PMGLPGEEDS GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL EGAARRAPSS VAHTSMSDNG GFKRPLAPSG RSPVEGLGRA HRSPASPRVP PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA TALAFLGSQS LAAPTDCVSS FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR GGLGNPATDR GEGPVELAHL AGPGSPEAEE WGSHHGGLQE VEALSGSVHS GSVPGLPPVE TVGFHGSRKR SRDHFRNKSS SPEDPGAEV Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: TSSC4 (Tumor Suppressing Subtransferable Candidate 4 (TSSC4))

Alternative Name: TSSC4

Background: U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein),FUNCTION: Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}.

Molecular Weight: 34.3 kDa

UniProt: Q9Y5U2

AlphaFold: Q9Y5U2