Cmah Protein (AA 1-501) (His tag)

Catalog No. ABIN7553492

This Recombinant Cmah protein is expressed in HEK-293 Cells.

Quick Overview for Cmah Protein (AA 1-501) (His tag) (ABIN7553492)

Target: Cmah (CMAHP) (Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase, Pseudogene (CMAHP))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-501

Purification tag / Conjugate: This Cmah protein is labelled with His tag.

Purpose: Predefined custom protein recombinant CMAHP Protein expressed in mammalian cells.

Sequence: MDENNGLLLL ELNPPNPWDL QPRSPEELAF GEVQITYLTH ACMDLKLGDK RMVFDPWLIG PAFARGWWLL HEPPSDWLER LCQADLIYIS HLHSDHLSYP TLKKLAGRRP DIPIYVGNTE RPVFWNLNQS GVQLTNINVV PFGIWQQVDK NLRFMILMDG VHPEMDTCII VEYKGHKILN IVDCTRPNGG RLPMKVALMM SDFAGGASGF PMTFSGGKFT EEWKAQFIKT ERKKLLNYKA RLVKNLQPRI YCPFAGYFVE SHPSDKYIKE TNTKNDPNEL NNLIKKNSDV ITWTPRPGAT LDLGRMLKDR TDSKGIIEPP EGTKIYKDSW DFEPYLEILN AALGDEIFLH SSWIKEYFTW AGFKDYNLVV RMIETDEDFN PFPGGYDYLV DFLDLSFPKE RPQREHPYEE IHSRVDVIRH VVKNGLLWDE LYIGFQTRLQ RDPDIYHHLF WNHFQIKLPL TPPNWKSFLM CCEQNGPVIL QFSTERTNEP NRNKFSVENK A Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: Cmah (CMAHP) (Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase, Pseudogene (CMAHP))

Alternative Name: CMAHP

Background: Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-NeuAc hydroxylase-like protein) (Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene),FUNCTION: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates (PubMed:9624188). However, it may play a role in Wnt signaling (PubMed:19890979). {ECO:0000269|PubMed:19890979, ECO:0000269|PubMed:9624188, ECO:0000303|PubMed:11562455, ECO:0000303|PubMed:12192086, ECO:0000303|PubMed:9751737}.

Molecular Weight: 58.4 kDa

UniProt: Q9Y471

AlphaFold: Q9Y471