SHC2 Protein (AA 1-573) (His tag)

Catalog No. ABIN7558760

This Recombinant SHC2 protein is expressed in HEK-293 Cells.

Quick Overview for SHC2 Protein (AA 1-573) (His tag) (ABIN7558760)

Target: SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-573

Purification tag / Conjugate: This SHC2 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Shc2 Protein expressed in mammalian cells.

Sequence: MTQGPGGRAA PEPEAPTTFC ALLPRMPQWK FAAPGSFLGR GPAATRVAGV AEAQPEPGVP ALAAVLGACE PRCAAPCPLP ALGRCRGSGT RGARVTPDVA DEWVRKGGFI HKPAHGWLHP DARVLGPGVS YIVRYMGCIE VLRSMRSLDF NTRTQVTREA INRLHEAVPG VRGSWKKKAP NKALASILGK SNLRFAGMSI SVNISVDGLN LSVPATRQII ANHHMQSISF ASGGDTDMTD YVAYVAKDPI NQRACHILEC CEGLAQSVIS TVGQAFELRF KQYLHSPPKA VVPPERLTGL EELAWGDDDA AADHNYYNSI PGKEPPLGGL VDSRLAVTQP CALATLGGLG QGMTPVWRDA RGLPWDMGPS GAAPPGDGYV QADARGPHDY EEHLYVNTQG LDAVELEDTA EAPLQFEDSP KKDLFDMRPF EDALKLHACS VAAGITAASP PLEDQWPSPP TRRAPIAPTE EQLRQEPWYH GRMSRRAAEK LLRADGDFLV RDSVTNPGQY VLTGMHAGQP KHLLLVDPEG VVRTKDVLFE SISHLIDYHL KNGLPIVAAE SELHLRGVVS REP Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))

Alternative Name: Shc2

Background: SHC-transforming protein 2 (Protein Sck) (Protein Sli) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2),FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Molecular Weight: 61.8 kDa

UniProt: Q8BMC3

AlphaFold: Q8BMC3

Pathways: RTK Signaling, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, VEGF Signaling