PPP2R3C Protein (AA 1-453) (His tag)

Catalog No. ABIN7561619

This Recombinant PPP2R3C protein is expressed in HEK-293 Cells.

Quick Overview for PPP2R3C Protein (AA 1-453) (His tag) (ABIN7561619)

Target: PPP2R3C (Protein Phosphatase 2, Regulatory Subunit B'', gamma (PPP2R3C))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-453

Purification tag / Conjugate: This PPP2R3C protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Ppp2r3c Protein expressed in mammalian cells.

Sequence: MDWKDVLRRR LASPNTDPKR KKSEQELKDE EMDLFTKYYS EWKGGRKNTN EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW FLLDKHQIPP MIGEEAMINY ENFLKVGEKA GPKCKQFFTA KVFAKLLHTD SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDNENSADL DDT Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: PPP2R3C (Protein Phosphatase 2, Regulatory Subunit B'', gamma (PPP2R3C))

Alternative Name: Ppp2r3c

Background: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR),FUNCTION: May regulate MCM3AP phosphorylation through phosphatase recruitment (PubMed:12167160). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (By similarity). May play a role in the activation-induced cell death of B-cells (PubMed:16129705, PubMed:16343422). {ECO:0000250|UniProtKB:Q969Q6, ECO:0000269|PubMed:12167160, ECO:0000269|PubMed:16129705, ECO:0000269|PubMed:16343422}.

Molecular Weight: 53.4 kDa

UniProt: Q9JK24

AlphaFold: Q9JK24

Pathways: PI3K-Akt Signaling