STAT2 Protein (AA 1-923) (His tag)

Catalog No. ABIN7565245

Product Details

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Protein Type: Recombinant

Protein Characteristics: AA 1-923

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This STAT2 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Stat2 Protein expressed in mammalian cells.

Sequence: MAQWEMLQNL DSPFLDQLHQ VYSQSFLPMD FRQHLASWIE DQNWREAALE SDDAKANMLY FSILDQLNQW DHYSSDPKSL LLQHNLRKFS RDIQPFPNGP SQLAEMIFNL LLEEQRILIQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAHVVQA TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP PVKSAAEQLE QWLTAGAKFL FHLRQLLKQL KEMSCLRYQG DMFAKGVDLR NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEKG QRQGLIWDFG FLTLVEQRAV GAGKGNNKGP LAVTEELHVI SFVVEYTYQG LKMKLQTDTL PVVIISNMNQ LSFAWASILW FNMLSPNPKN QQFFCQAPKA PWSLLGPVLS WQFSSYVARG LDSEQLGMLR TKLFGKSCKM EDALLSWVDF CKRESPPGKI PFWTWLDKIL ELVHDHLKDL WKDGRIMGFV SRNQERRLLK KMLSGTFLLR FSETSEGGIT CSWVEHQDDH KVEIYSVQPY TKEVLQSLPL TEIIRHYQVL AEENIPENPL RFLYPRIPRD EAFGCYYQEK VNLEEQEEYL KHKLIVISNR QVDELQQPLE LKQDSESLEV NAELLLAHDQ ELPLMMQTGL VLGTELKVDP ILSTAPQVLL EPAPQVLLEP APQVLLEPAP QVLLEPAPQV LLEPAPQVLL EPAPQVLLEP APQVQLEPAP QVLLELAPQV LLEPAPQVLL ELAPQVQLEP AHLLQQPSES DLPEDLQQIS VEDLKKLSNP STEYITTNEN PMLAGESSGD ETSIPYHSHF DADGLLGWTL DTF Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Alternative Name: Stat2 (STAT2 Products)

Background: Signal transducer and activator of transcription 2,FUNCTION: Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. {ECO:0000250|UniProtKB:P52630}.

Molecular Weight: 105.4 kDa

UniProt: Q9WVL2

AlphaFold: Q9WVL2

Pathways: JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events