CD74 Protein (AA 56-215) (Fc Tag)
Quick Overview for CD74 Protein (AA 56-215) (Fc Tag) (ABIN7566124)
Target
See all CD74 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 56-215
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Purification tag / Conjugate
- This CD74 protein is labelled with Fc Tag.
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Purpose
- CD74 (mouse):Fc (mouse) (rec.)
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Cross-Reactivity
- Mouse
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Characteristics
- The extracellular domain of mouse CD74 (aa 56-215) is fused to the N-terminus of the Fc region of mouse IgG2a.
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Sterility
- Sterile filtered
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Endotoxin Level
- <5EU/mg protein (LAL test, Lonza).
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HLA-DR-gamma (CD74) (AA 1-296) protein (His tag)
custom-made CD74 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
HLA-DR-gamma (CD74) (AA 1-279) protein (His tag)custom-made CD74 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
HLA-DR-gamma (CD74) (AA 56-279) protein (His tag)CD74 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
HLA-DR-gamma (CD74) (AA 1-160) protein (GST tag)CD74 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
HLA-DR-gamma (CD74) protein (His tag)CD74 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
HLA-DR-gamma (CD74) protein (His tag,mFc Tag)CD74 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
HLA-DR-gamma (CD74) (AA 73-232) protein (His tag)CD74 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
HLA-DR-gamma (CD74) protein (Fc Tag)CD74 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
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Handling Advice
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- CD74 (HLA-DR-gamma (CD74))
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Alternative Name
- CD74
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Background
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CLIP, DHLAG, HLADG
CD74 is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. The cytoplasmic portion of CD74 can be released by intramembrane cleavage to activate NFkB. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation.
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Molecular Weight
- ~55kDa (SDS-PAGE)
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NCBI Accession
- NP_034675
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Pathways
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
Target
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