IL21 Receptor Protein (AA 20-234) (Fc Tag)

Catalog No. ABIN7566242

This Recombinant IL21 Receptor protein is produced in CHO Cells.

Quick Overview for IL21 Receptor Protein (AA 20-234) (Fc Tag) (ABIN7566242)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: CHO Cells

Purity: >98 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 20-234

Purification tag / Conjugate: This IL21 Receptor protein is labelled with Fc Tag.

Purpose: IL-21R (mouse):Fc (mouse) (rec.) (non-lytic)

Cross-Reactivity: Mouse

Characteristics: The extracellular domain of mouse IL-21R (aa 20-234) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.

Sterility: Sterile filtered

Endotoxin Level: <1EU/mg protein (LAL test, Lonza).

Biological Activity Comment: Shows the biological function of the IL-21R moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: IL-21R

Background:

Interleukin-21 Receptor, CD360, NILR

Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gammac) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth, IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).

Molecular Weight: ~50-100kDa

Pathways: JAK-STAT Signaling