delta-Dendrotoxin (Active) Protein
Native delta-Dendrotoxin protein expressed in Dendroaspis angusticeps (Eastern green mamba).
Catalog No. ABIN7821949
$1,993.23
Plus shipping costs $50.00
Shipping to:
United States
Delivery in 11 to 14 Business Days
Quick Overview for delta-Dendrotoxin (Active) Protein (ABIN7821949)
Target
delta-Dendrotoxin
Protein Type
Native
Biological Activity
Active
Origin
Dendroaspis angusticeps
Source
Dendroaspis angusticeps (Eastern green mamba)
Purity
≥98 % (HPLC)
-
-
Purpose
- δ-Dendrotoxin
-
Sequence
- AAKYCKLPVR YGPCKKKIPS FYYKWKAKQC LPFDYSGCGG NANRFKTIEE CRRTCVG-OH
-
Specificity
- Toxin target: KV1.1, KV1.6 and Kir1.1/ROMK1 potassium channels
-
Biological Activity Comment
- δ-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K+ channels (KV1.1, KV1.2 and KV1.6). In addition δ-Dendrotoxin inhibits ROMK1 channel currents.
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
-
Application Notes
- Antigen Preadsorption Control: 10 - 100 nM
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial and dissolve by gently tapping, tilting, or rolling the vial. Avoid vigorous vortexing, a brief, light vortex of 1-2 seconds is acceptable if necessary. The product is readily soluble in high-quality pure water at micromolar to millimolar concentrations (typically 100 μM to 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x the final working concentration. Divide the stock solution into small, single-use aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh working solutions just before use. Avoid multiple freeze-thaw cycles to maintain optimal biological activity.
-
Buffer
- Lyophilized from double distilled water (ddH2O). May contain residual trifluoroacetate (TFA).
-
Handling Advice
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom,Avoid multiple freeze-thaw cycles to maintain optimal biological activity,Avoid vigorous vortexing. protect from moisture
-
Storage
- -20 °C
-
Storage Comment
- The product is shipped as a lyophilized powder at room temperature. Upon receipt, store at -20°C and protect from moisture.
-
-
- delta-Dendrotoxin
-
Background
- A potent and specific blocker of KV1.1 channels, with lower potency for KV1.6 and Kir1.1 (ROMK1) channels
-
Molecular Weight
- 6568 Da
-
UniProt
- P00982
Target
-
You are here:
