GDF15 Protein (AA 99-330) (Fc Tag)
Quick Overview for GDF15 Protein (AA 99-330) (Fc Tag) (ABIN7597361)
Target
See all GDF15 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 99-330
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Purification tag / Conjugate
- This GDF15 protein is labelled with Fc Tag.
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Purpose
- Recombinant mouse GDF15 protein with N-terminal human Fc tag
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Specificity
- HFc(Glu99-Ala330) Mouse GDF15(Ser189-Ala303)
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Characteristics
- Extracellular Domain Protein
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Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (His tag)
GDF15 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (hFc Tag)GDF15 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (hFc Tag,Biotin)GDF15 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 193-308) (Active) protein (His tag)GDF15 Origin: Cynomolgus Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 197-307) (Active) protein (His tag)GDF15 Origin: Dog Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (hFc Tag,Biotin)GDF15 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 189-303) (Active) protein (hFc Tag,Biotin)GDF15 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (Biotin,His-Avi Tag)GDF15 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 31-308) protein (GST tag)GDF15 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- GDF15 (Growth Differentiation Factor 15 (GDF15))
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Alternative Name
- GDF15
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Background
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SBF, MIC-1, NAG-1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016] -
Molecular Weight
- predicted molecular mass of 38.7 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mGDF15 is 35-55 kDa due to glycosylation.
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UniProt
- Q9Z0J7
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Pathways
- SARS-CoV-2 Protein Interactome
Target
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