WFDC2 Protein (AA 31-124) (Fc Tag)

Catalog No. ABIN7597410

Recombinant WFDC2 protein expressed in HEK-293 Cells.

Quick Overview for WFDC2 Protein (AA 31-124) (Fc Tag) (ABIN7597410)

Target: WFDC2 (WAP Four-Disulfide Core Domain 2 (WFDC2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 31-124

Purification tag / Conjugate: This WFDC2 protein is labelled with Fc Tag.

Purpose: Recombinant human HE4 Protein with C-terminal human Fc tag

Sequence: HE4(Glu31-Phe124) hFc(Glu99-Ala330)

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: WFDC2 (WAP Four-Disulfide Core Domain 2 (WFDC2))

Alternative Name: HE4

Background: WFDC2, WAP5, EDDM4, dJ461P17.6
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Molecular Weight: predicted molecular mass of 36.2 kDa after removal of the signal peptide. The apparent molecular mass of HE4-hFc is 35-55 kDa due to glycosylation.

UniProt: Q14508