CSK Protein (His-GST)
Quick Overview for CSK Protein (His-GST) (ABIN7668267)
Target
See all CSK ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This CSK protein is labelled with His-GST.
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Purpose
- Recombinant Mouse SRC Kinase/c-SRC Protein (His & GST Tag)
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Sequence
- Met 1-Leu 535
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Purification
- > 95 % as determined by reducing SDS-PAGE.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be > 80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.
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C-Src tyrosine Kinase (CSK) (AA 1-450) protein (GST tag)
CSK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
C-Src tyrosine Kinase (CSK) (Active) protein (GST tag,His tag)CSK Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 85 % as determined by SDS-PAGE Active
C-Src tyrosine Kinase (CSK) (Active) protein (GST tag)CSK Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE. Active
C-Src tyrosine Kinase (CSK) proteinCSK Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
C-Src tyrosine Kinase (CSK) (AA 1-450) protein (His tag)CSK Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95% by SDS-PAGE SDS
C-Src tyrosine Kinase (CSK) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)CSK Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- CSK (C-Src tyrosine Kinase (CSK))
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Alternative Name
- SRC Kinase
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Background
- Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.,AW259666,pp60c-src
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Molecular Weight
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calculated_mw: 87.7 kDa
observed_mw: 80 kDa
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Pathways
- TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
Target
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