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Occludin Protein (OCLN) (His tag)

This Recombinant Occludin protein is produced in Escherichia coli (E. coli).
Catalog No. ABIN7669390

Quick Overview for Occludin Protein (OCLN) (His tag) (ABIN7669390)

Target

See all Occludin (OCLN) Proteins
Occludin (OCLN)

Protein Type

Recombinant

Biological Activity

Inactive

Origin

  • 8
  • 4
  • 3
Human

Source

  • 8
  • 3
  • 2
  • 2
Escherichia coli (E. coli)

Purity

> 90 %
  • Purification tag / Conjugate

    This Occludin protein is labelled with His tag.

    Purpose

    Recombinant Human OCLN Protein(His Tag)

    Sequence

    Lys266~Thr522

    Purification

    SDS-PAGE analysis of Human OCLN proteins, 2 μg/lane of Recombinant Human OCLN proteins was resolved with an SDS-PAGE under reducing conditions, showing bands at 28 KD

    Sterility

    0.2 μm filtered

    Endotoxin Level

    < 10 EU/mg of the protein as determined by the LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

    Buffer

    Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.

    Storage

    4 °C,-20 °C,-80 °C

    Storage Comment

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

    Expiry Date

    12 months
  • Target

    Occludin (OCLN)

    Alternative Name

    OCLN

    Background

    This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with an simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.,BLCPMG,FLJ08163,FLJ18079,FLJ77961,FLJ94056,MGC34277,Occludin,Ocln,OCLN,Phosphatase 1 regulatory subunit 115,PPP1R115,PTORCH1,Tight junction protein occludin

    Molecular Weight

    calculated_mw: 28 kDa

    observed_mw: 42 kDa

    UniProt

    Q16625

    Pathways

    Cell-Cell Junction Organization, Hepatitis C
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