VEGF (Aflibercept Biosimilar) Protein (Fc Tag)

Catalog No. ABIN7795087

This Recombinant VEGF (Aflibercept Biosimilar) protein is expressed in CHO Cells.

Quick Overview for VEGF (Aflibercept Biosimilar) Protein (Fc Tag) (ABIN7795087)

Target: VEGF (Aflibercept Biosimilar)

Protein Type: Recombinant

Origin: Human

Source: CHO Cells

Application: In vivo Studies (in vivo)

Purity: >95% by SDS-PAGE under reducing conditions and HPLC

Grade: Research Grade

Product Details

Purification tag / Conjugate: This VEGF (Aflibercept Biosimilar) protein is labelled with Fc Tag.

Purpose: Recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (hIgG1).

Specificity: The aflibercept biosimilar protein specifically binds to the human VEGF.

Characteristics: Research grade Aflibercept biosimilar has the same amino acid sequence as Aflibercept (trade name Eylea), a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (IgG1). It inhibits vascular endothelial growth factor (VEGF), and is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Aflibercept is a dimeric glycoprotein with a molecular weight of 96.9 kilo Daltons (kDa). Glycosylation adds its molecular weight to 115 kDa in total. Ziv-aflibercept (trade name Zaltrap) was developed as an injection for treatment of metastatic colorectal cancer.

Purification: The aflibercept biosimilar protein was produced in CHO stable cell line.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1 EU per 1 mg of the protein by the LAL method

Application Details

Application Notes: Functional assays, and those assays for studying biological pathways affected by aflibercept.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: pH 6.1, no stabilizers or preservatives

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Expiry Date: 12 months

Target Details

Target: VEGF (Aflibercept Biosimilar)

Alternative Name: Aflibercept Biosimilar

Target Type: Biosimilar