Abeta 1-42 Protein

Catalog No. ABIN7849653

Recombinant Abeta 1-42 protein expressed in Escherichia coli (E. coli).

Quick Overview for Abeta 1-42 Protein (ABIN7849653)

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: ELISA, Western Blotting (WB)

Purity: >85 % by SDS-PAGE

Product Details

Purpose: Recombinant Human Amyloid beta 1-42, AB1-42 Protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01M PBS, pH 7.5.

Storage: 4 °C,-20 °C

Storage Comment: Ship at 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.

Target Details

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Alternative Name: AB1-42

Background:

Synonyms: Beta Amyloid(1-42), beta Amyloid 1-42, beta-Amyloid 1-42, Amyloid 1-42, A4, ABETA, ABPP, Alzheimers Disease Amyloid Protein, Amyloid B, Amyloid Beta A4 Protein Precursor, Amyloid Beta, Amyloid of Aging and Alzheimer Disease, B Amyloid, Beta APP, Cerebral Vascular Amyloid Peptide, Beta-amyloid protein 42

Description: Recombinant mature human AB1-42 protein.

Background: Amyloid beta (Aβ or Abeta) denotes peptides of 36-43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. Oligomeric amyloid-β 1-42 (Aβ-42) peptides are considered to be the most toxic species connected to the occurrence of Alzheimer's disease. Unstructured oligomeric Aβ-42 interacted with membrane bilayers of giant unilamellar vesicles (GUV) and neuronal model cells, facilitated cellular uptake of Aβ-42, and inhibition of mitochondrial activity. Elevated concentrations of glucose within the range observed in diabetic individuals (10 mM) facilitate the formation of membrane-active Aβ-42 oligomers.