Creatine Kinase MB Protein (CKM)

Catalog No. ABIN7849673

This Native Creatine Kinase MB protein is expressed in Human.

Quick Overview for Creatine Kinase MB Protein (CKM) (ABIN7849673)

Target: Creatine Kinase MB (CKM)

Protein Type: Native

Origin: Human

Source: Human

Application: Immunoassay (IA)

Product Details

Purpose: Native Human Creatine kinase MB,CK-MB protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris-HCl pH 8.0, 5 mM beta Mercaptoethano and 6 % Sugrose.

Storage: 4 °C,-20 °C

Storage Comment: Ship at 4°C.Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.

Target Details

Target: Creatine Kinase MB (CKM)

Alternative Name: Creatine kinase MB

Background:

Synonyms: CK-MB, B-CK, brain creatine kinase, CKBB, CKMB, CKMM, creatine kinase B, creatine kinase brain, creatine kinase M, Creatine kinase MB, Creatine Kinase MB type, creatine kinase muscle, M-CK, creatine kinase-M/B, KCRB_HUMAN, muscle creatine kinase

Description: Purified Creatine Kinase-MB Isoenzyme Protein.

Background: Creatine kinase isoenzyme-MB (CK-MB) is a biomarker for detecting myocardial injury. It is a simple, widely available, and useful biomarker for predicting adverse in-hospital clinical outcomes in pulmonary embolism. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The CK-MB-to-total-CK ratio is an easily available indicator and could be clinically utilized as a primary screening tool for cancer. Higher ratio of CK-MB-to-total-CK was specifically associated with certain malignancies, like colorectal cancer, lung cancer and hepatocellular carcinoma, as well as some cancer-associated status factors such as advanced stage and liver metastasis.