CD80 Protein (CD80)
Quick Overview for CD80 Protein (CD80) (ABIN7849732)
Target
See all CD80 ProteinsProtein Type
Origin
Source
Application
Purity
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Purpose
- Recombinant Human CD80 Protein
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Endotoxin Level
- <1.0EU per μg of the protein as determined by the LAL method
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CD80 (CD80) (AA 35-242) (Active) protein (Biotin,His-Avi Tag)
CD80 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD80 (CD80) (AA 35-242) (Active) protein (His-Avi Tag)CD80 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD80 (CD80) (AA 35-242) protein (His tag,mFc Tag)CD80 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
CD80 (CD80) (AA 35-242) protein (His tag)HPLC verified CD80 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
CD80 (CD80) (AA 137-230) protein (His-DYKDDDDK-Strep II Tag)CD80 Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD80 (CD80) (AA 35-242) protein (His-DYKDDDDK-Strep II Tag)CD80 Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD80 (CD80) (AA 38-245) (Active) protein (Fc Tag)CD80 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD80 (CD80) (AA 35-242) (Active) protein (Fc Tag,AVI tag,Biotin)CD80 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
CD80 (CD80) (AA 35-242) (Active) protein (His tag)CD80 Origin: Human Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, ELISA, Imm, AcA Active
CD80 (CD80) (Active) protein (His tag)CD80 Origin: Mouse Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from sterile PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Ship at 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
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- CD80
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Alternative Name
- CD80
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Background
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Synonyms: B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Description: Recombinant human CD80 protein at the C-terminus.
Background: The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
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Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
Target
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