GAD65 Protein
Quick Overview for GAD65 Protein (ABIN7849739)
Target
See all GAD65 (GAD2) ProteinsProtein Type
Origin
Source
Application
Purity
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Purpose
- Recombinant Human Glutamic Acid Decarboxylase65,GAD65Protein
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Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) (AA 1-585) protein (GST tag)
GAD2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) protein (GST tag,His tag)GAD2 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 92 % as determined by SDS-PAGE
Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) protein (GST tag)GAD2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) proteinGAD2 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GAD2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Tris-HCl, pH 7.4±0.2 with 0.02 % Sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Ship at 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.
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- GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
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Alternative Name
- GAD65
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Background
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Synonyms: 65 kDa glutamic acid decarboxylase, DCE 2, DCE2, GAD 2, GAD 65, GAD-2, GAD-65, GAD 65, GAD2, Glutamate Decarboxylase 2 (pancreatic islets and brain 65 kDa), Glutamate Decarboxylase 2, Glutamate Decarboxylase 65, Glutamate decarboxylase 65 kDa isoform, Glutamic Acid Decarboxylase 2, Glutamic Acid Decarboxylase 65.
Description: Recombinant human Glutamic Acid Decarboxylase 65 protein with his tag at N-terminal with molecular weight of 80 kDa.
Background: Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. In mammals, GAD exists in two isoforms encoded by two different genes - GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 and 65 kDa, respectively. GAD65 and GAD67 synthesize GABA at different locations in the cell, at different developmental times, and for functionally different purposes. GAD67 is spread evenly throughout the cell while GAD65 is localized to nerve terminals. Gad67 in Drd1a-expressing neurons plays a key role in the development of LID and they support the hypothesis that altered GABAergic neurotransmission in the direct pathway is involved in dyskinesia.
Target
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