Glutamic Acid Decarboxylase Protein (GAD)
Quick Overview for Glutamic Acid Decarboxylase Protein (GAD) (ABIN7849740)
Target
Protein Type
Origin
Source
Application
Purity
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Purpose
- Recombinant Human Glutamic Acid Decarboxylase230,GAD230 Protein
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Tris-HCl, pH 7.4±0.2 with 0.02 % Sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Ship at 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.
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- Glutamic Acid Decarboxylase (GAD)
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Alternative Name
- GAD230
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Background
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Synonyms: Glutamic Acid Decarboxylase, Glutamic Acid Decarboxylase 230, GAD230
Description: Recombinant human Glutamic Acid Decarboxylase 230 protein with molecular weight of 45 kDa.
Background: Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. In mammals, GAD exists in two isoforms encoded by two different genes - GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 and 65 kDa, respectively. GAD65 and GAD67 synthesize GABA at different locations in the cell, at different developmental times, and for functionally different purposes. GAD67 is spread evenly throughout the cell while GAD65 is localized to nerve terminals. Gad67 in Drd1a-expressing neurons plays a key role in the development of LID and they support the hypothesis that altered GABAergic neurotransmission in the direct pathway is involved in dyskinesia.
Target
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