CXCL12 Protein
Quick Overview for CXCL12 Protein (ABIN7866195)
Target
See all CXCL12 ProteinsProtein Type
Origin
Source
Application
Purity
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Purpose
- SDF1 – Stromal Cell-Derived Factor 1α ( CXCL12) tested in migration, LPS-Free
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Sequence
- CXCL12 consists of 69 amino acid residues: MKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK
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Characteristics
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Recombinant Stromal Cell-Derived Factor 1α (SDF-1alpha) is a 8 kDa chemokine protein expressed in many tissues and cell types. The protein is almost identical (92% homology) in human, mouse and rat.
The chemokine SDF-1α binds to the chemokine receptor CXCR4 and plays an essential and unique role in homeostatic regulation of leukocyte traffic, hematopoiesis, organogenesis, cell differentiation and tissue regeneration (Murphy, 2002).
SDF-1alpha forms an heterocomplex with the alarmin HMGB1 (High Mobility Group 1) to promote the recruitment of cells via CXCR4 receptor. -
Purification
- Purified
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Endotoxin Level
- LPS-free: Pierce™ Chromogenic Endotoxin Quant Kit, <0.1 EU/mL
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Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) (Active) protein (His tag,GST tag)
CXCL12 Origin: Human Host: Escherichia coli (E. coli) > 97 % AcA, CC Active
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 24-89) (Active) protein (Biotin)CXCL12 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 97 % by SDS PAGE FACS, CMA Active
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 1-89) protein (GST tag)CXCL12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) protein (His tag)CXCL12 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (Active) proteinCXCL12 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) protein (His tag)CXCL12 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) protein (His-IF2DI Tag)CXCL12 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) protein (His-IF2DI Tag)CXCL12 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) proteinCXCL12 Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) proteinCXCL12 Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- The lyophilized protein once reconstituted with distilled water will be dissolved in a solution of DPBS without Ca and Mg.
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Buffer
- The product contains contains < 0.006% v/v of Triton X-114 due to LPS removal. Remaining traces can be removed upon request.
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Storage
- 4 °C/-20 °C
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Storage Comment
- 2-8°C when lyophilized. The protein once reconstituted with water can be stored frozen (-20°C). Avoid repeated freezing and thawing.
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- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
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Alternative Name
- SDF1 alpha
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Molecular Weight
- 8 kDa
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Pathways
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
Target
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