BMP2 Protein
Quick Overview for BMP2 Protein (ABIN7866430)
Target
See all BMP2 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purpose
- Recombinant Human BMP-2 Protein
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Sequence
- MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
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Specificity
- Chromosomal location:20p12
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Characteristics
- Length (aa):115
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Endotoxin Level
- < 0.1 ng per μg of BMP-2
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Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) (Active) protein
BMP2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as analyzed by non-reducing SDS-PAGE. Active
Bone Morphogenetic Protein 2 (BMP2) (AA 1-396) protein (GST tag)BMP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 231-330) protein (GST tag)BMP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) protein (GST tag)BMP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) protein (Fc Tag)BMP2 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Bone Morphogenetic Protein 2 (BMP2) proteinBMP2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by reducing SDS-PAGE. AM, ADA, IA, ScA
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) (Active) proteinBMP2 Origin: Human, Dog, Rat, Mouse, Rhesus Monkey Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Bone Morphogenetic Protein 2 (BMP2) (AA 284-396) proteinBMP2 Origin: Human Host: Escherichia coli (E. coli) Recombinant >92 % as determined by SDS-PAGE.
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Application Notes
- Measured by the ability of BMP-2 to induce alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 0.3-0.8 μg/mL.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- 50 mM acetic acid,The lyophilized BMP-2 is best soluble in 50 mM acetic acid at a concentration of 0.1 mg/mL but should be also soluble in most aqueous buffers when the pH is below 6.0.
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Buffer
- 50 mM acetic acid
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted BMP-2 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles!
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Expiry Date
- 6 months
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- BMP2 (Bone Morphogenetic Protein 2 (BMP2))
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Alternative Name
- BMP-2
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Background
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Synonyms: bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6
Description: Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. BMP-2 is a heparin binding protein.
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Molecular Weight
- 26.0 kDa
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Gene ID
- 650
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NCBI Accession
- NM_001200, NP_001191
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UniProt
- P12643
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Pathways
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation
Target
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