YWHAB Protein
Quick Overview for YWHAB Protein (ABIN7938556)
Target
See all YWHAB ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant YWHAB protein
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14-3-3 alpha + beta (YWHAB) (AA 1-246) protein (His tag)
custom-made YWHAB Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
14-3-3 alpha + beta (YWHAB) (AA 1-246) protein (His tag)custom-made YWHAB Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
14-3-3 alpha + beta (YWHAB) (AA 1-246) protein (GST tag)YWHAB Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
14-3-3 alpha + beta (YWHAB) (AA 1-246) proteinYWHAB Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % pure SDS
14-3-3 alpha + beta (YWHAB) (AA 1-246) protein (His-IF2DI Tag)YWHAB Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
14-3-3 alpha + beta (YWHAB) (AA 1-246) protein (His tag)YWHAB Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant YWHAB protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- YWHAB (14-3-3 alpha + beta (YWHAB))
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Alternative Name
- YWHAB
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Background
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Protein Background: YWHAB (14-3-3 protein beta/alpha) is a member of the highly conserved 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Short Description: Recombinant YWHAB protein that includes full length of human YWHAB protein (accession number NP_003395.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 30.25 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: KCIP-1, 14-3-3 protein beta/alpha, protein 1054, GW128
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Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, Maintenance of Protein Location
Target
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