CTBP2 Protein

Catalog No. ABIN7938669

This Recombinant CTBP2 protein is expressed in Escherichia coli (E. coli).

Quick Overview for CTBP2 Protein (ABIN7938669)

Target: CTBP2 (C-terminal Binding Protein 2 (CTBP2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Purpose: Recombinant CTBP2 protein

Characteristics: CTBP2 (C-Terminal Binding Protein 2), also written as CtBP2, is a protein that binds to the C-terminus of adenovirus E1A proteins. It ubiquitously expresses with 2 higher level in heart, skeletal muscle, pancreas, associating to adenovirus E1A,C terminal proteins, involved with histone deacetylase and E2F3 in transcription repression. CTBP2 is a corepressor targeting diverse transcription regulators. It functions in brown adipose tissue (BAT) differentiation (By similarity). CTBP1 gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. This product is isoform 1. CTBP2 and another C-Terminal Binding Protein, CTBP1 can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant CTBP2 protein is supplied in 25 mM Tris-HCl pH 8.0, 500 mM NaCl, 10 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: CTBP2 (C-terminal Binding Protein 2 (CTBP2))

Alternative Name: CTBP2

Background:

Protein Background: CTBP2 (C-Terminal Binding Protein 2), also written as CtBP2, is a protein that binds to the C-terminus of adenovirus E1A proteins. It ubiquitously expresses with 2 higher level in heart, skeletal muscle, pancreas, associating to adenovirus E1A, C terminal proteins, involved with histone deacetylase and E2F3 in transcription repression. CTBP2 is a corepressor targeting diverse transcription regulators. It functions in brown adipose tissue (BAT) differentiation (By similarity). CTBP1 gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. This product is isoform 1. CTBP2 and another C-Terminal Binding Protein, CTBP1 can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development.

Short Description: Recombinant CTBP2 protein was expressed in E.coli as the full length protein (accession number NP_001320.1) with an N-terminal 6xHis Tag. The molecular weight of the protein is 52.5 kDa.

Aliases: C-terminal binding protein 2