beta Catenin Protein
Quick Overview for beta Catenin Protein (ABIN7938678)
Target
See all beta Catenin (CATNB) ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant beta-Catenin protein
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant beta-Catenin protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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Alternative Name
- beta-Catenin
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Background
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Protein Background: beta-Catenin is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.
Short Description: Recombinant beta-Catenin protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001091679.1) with an N-terminal FLAG tag. The molecular weight of beta-Catenin is 86.79 kDa.
Aliases: CTNNB1, catenin beta 1, armadillo, CTNNB, NEDSDV, MRD19, EVR7
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Pathways
- Peptide Hormone Metabolism
Target
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