PD-L1 Protein (AA 19-239)
Quick Overview for PD-L1 Protein (AA 19-239) (ABIN7938682)
Target
See all PD-L1 ProteinsProtein Type
Origin
Source
Application
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Protein Characteristics
- AA 19-239
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Purpose
- Recombinant PD-L1 / CD274 (19-239) protein
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CD274 (PD-L1) (AA 19-238) (Active) protein (Biotin,His-Avi Tag)
PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD274 (PD-L1) (AA 19-238) protein (His tag,mFc Tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
CD274 (PD-L1) (AA 19-238) (Active) protein (His tag)PD-L1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD274 (PD-L1) (AA 19-238) (Active) protein (mFc Tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD274 (PD-L1) (AA 19-238) (Active) protein (Biotin,His tag)PD-L1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD274 (PD-L1) (AA 19-238) (Active) protein (hFc Tag)PD-L1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD274 (PD-L1) (AA 19-238) (Active) protein (Biotin,His tag)PD-L1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD274 (PD-L1) (AA 19-238) (Active) protein (His tag,AVI tag,Biotin)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD274 (PD-L1) (AA 18-238) protein (His-DYKDDDDK-Strep II Tag)PD-L1 Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD274 (PD-L1) (AA 19-238) (Active) protein (Fc Tag)PD-L1 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant PD-L1 / CD274 (19-239) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PD-L1 (CD274 (PD-L1))
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Alternative Name
- PD-L1 & CD274
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Background
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Protein Background: PD-L1 is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. It plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, PD-L1 may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Short Description: Recombinant PD-L1 / CD274 (19-239) protein that includes amino acids 19-239 of human PD-L1 protein (accession number NP_054862.1) was expressed in a baculovirus expression system, and contains an C-terminal FLAG tag. The molecular weight of the protein is 27.1 kDa.
Aliases: B7-H1
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Pathways
- Cancer Immune Checkpoints
Target
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