CHD1L Protein
Quick Overview for CHD1L Protein (ABIN7938710)
Target
See all CHD1L ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant CHD1L protein
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Chromodomain Helicase DNA Binding Protein 1-Like (CHD1L) protein (Myc-DYKDDDDK Tag)
CHD1L Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant CHD1L protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like (CHD1L))
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Alternative Name
- CHD1L
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Background
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Protein Background: CHD1L is a ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.
Short Description: Recombinant CHD1L protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_004275.4) with an N-terminal FLAG tag. The molecular weight of CHD1L is 102.27 kDa.
Aliases: ALC1, Amplified In Liver Cancer Protein 1, CHDL
Target
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