CRTC1 Protein
Quick Overview for CRTC1 Protein (ABIN7938727)
Target
See all CRTC1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant CRTC1 protein
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CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 553-634) protein (GST tag)
CRTC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
CREB Regulated Transcription Coactivator 1 (CRTC1) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)CRTC1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
CREB Regulated Transcription Coactivator 1 (CRTC1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)CRTC1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant CRTC1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
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Alternative Name
- CRTC1
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Background
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Protein Background: CRTC1 as a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in latephase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Short Description: Recombinant CRTC1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_056136.2) with an N-terminal FLAG tag. The molecular weight of CRTC1 is 68.57 kDa.
Aliases: CREB Regulated Transcription Coactivator 1, TORC1, MECT1, WAMTP1, MAML2
Target
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