DDX3X Protein

Catalog No. ABIN7938752

This Recombinant DDX3X protein is produced in Baculovirus infected Insect Cells.

Quick Overview for DDX3X Protein (ABIN7938752)

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Purpose: Recombinant DDX3X protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant DDX3X protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Alternative Name: DDX3X

Background:

Protein Background: DDX3X (ATP-dependent RNA helicase DDX3X) is a multifunctional ATP-dependent RNA helicase belonging to the DEAD-box protein family, which is critically involved in numerous aspects of RNA metabolism. Its primary function is to unwind RNA secondary structures, an essential activity that facilitates key processes including transcription, mRNA splicing, nuclear export, translation initiation, and the assembly of stress granules. Furthermore, DDX3X plays vital roles in innate immune signaling pathways by modulating the activity of key kinases and interferon responses. Due to its central role in gene expression and cell growth, mutations in the DDX3X gene are linked to neurodevelopmental disorders and various cancers, highlighting its importance in cellular homeostasis and disease.

Short Description: Recombinant DDX3X protein was expressed in a baculovirus expression system as the full length protein (accession number NP_001347.3) with an N-terminal FLAG tag. The molecular weight of DDX3X is 74.51 kDa.

Aliases: ATP-dependent RNA helicase DDX3X, DEAD-Box Helicase, DDX3X, DDX3, HLP2

Pathways: Ribonucleoprotein Complex Subunit Organization, Positive Regulation of Endopeptidase Activity, Negative Regulation of intrinsic apoptotic Signaling, Ribosome Assembly