FRK Protein (AA 208-505)
Quick Overview for FRK Protein (AA 208-505) (ABIN7938852)
Target
See all FRK ProteinsProtein Type
Origin
Source
Application
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Protein Characteristics
- AA 208-505
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Purpose
- Recombinant FRK (208-505) protein
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Fyn-Related Kinase (FRK) (AA 1-505) protein (His tag)
custom-made FRK Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Fyn-Related Kinase (FRK) (AA 1-512) protein (His tag)custom-made FRK Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Fyn-Related Kinase (FRK) (AA 1-505) protein (GST tag)FRK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fyn-Related Kinase (FRK) (AA 391-505) protein (GST tag)FRK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant FRK (208-505) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- FRK (Fyn-Related Kinase (FRK))
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Alternative Name
- FRK
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Background
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Protein Background: FRK is a non-receptor tyrosine-protein kinase that negatively regulates cell proliferation and positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth and may function as a tumor suppressor. Diseases associated with FRK include Co-Trimoxazole Allergy and Osseous Heteroplasia, Progressive.
Short Description: Recombinant FRK (208-505) protein that includes amino acids 208-505 of human FRK protein (accession number NP_002022.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 36.5 kDa
Aliases: Fyn-related kinase, Rak
Target
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