MAP4K6 Protein (AA 1-320)
Quick Overview for MAP4K6 Protein (AA 1-320) (ABIN7939315)
Target
See all MAP4K6 (MINK1) ProteinsProtein Type
Origin
Source
Application
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Protein Characteristics
- AA 1-320
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Purpose
- Recombinant MINK1 (1-320) protein
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Misshapen-Like Kinase 1 (MINK1) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)
MINK1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Buffer
- Recombinant MINK1 (1-320) protein is supplied at a concentration of 0.25 μg/ul in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))
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Alternative Name
- MINK1
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Background
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Protein Background: MINK1 (Misshapen Like Kinase 1) is a serine/threonine kinase which acts as a negative regulator of Rasrelated Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. MINK1 is required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. MINK1 can activate the JNK and MAPK14/p38 pathways and mediate stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Diseases associated with MINK1 include Alzheimer Disease 15 and Shipyard Eye.
Short Description: Recombinant MINK1 (1-320) protein that includes amino acids 1-320 of human MINK1 protein (accession number NP_722549.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 37.7 kDa.
Aliases: Misshapen Like Kinase 1
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Pathways
- Synaptic Membrane
Target
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