MYST3 Protein (AA 488-778)

Catalog No. ABIN7939357

This Recombinant MYST3 protein is expressed in Baculovirus infected Insect Cells.

Quick Overview for MYST3 Protein (AA 488-778) (ABIN7939357)

Target: MYST3 (MYST Histone Acetyltransferase (Monocytic Leukemia) 3 (MYST3))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Protein Characteristics: AA 488-778

Purpose: Recombinant KAT6A / MOZ (488-778) protein

Characteristics: KAT6A (Lysine Acetyltransferase 6A), also called as MOZ, MYST3 or ZNF220, is a histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). It is a component of the MOZ / MORF complex which has a histone H3 acetyltransferase activity. KAT6A may act as a transcriptional coactivator for RUNX1 and RUNX2. It also acetylates p53 / TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. This protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant KAT6A / MOZ (488-778) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: MYST3 (MYST Histone Acetyltransferase (Monocytic Leukemia) 3 (MYST3))

Alternative Name: KAT6A & MOZ

Background:

Protein Background: KAT6A (Lysine Acetyltransferase 6A), also called as MOZ, MYST3 or ZNF220, is a histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). It is a component of the MOZ / MORF complex which has a histone H3 acetyltransferase activity. KAT6A may act as a transcriptional coactivator for RUNX1 and RUNX2. It also acetylates p53 / TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. This protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain.

Short Description: Recombinant KAT6A / MOZ (488-778) protein that includes amino acids 488-778 of human KAT6A protein (accession number NP_006757.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 35.5 kDa. This product is the catalytic domain of KAT6A protein.

Aliases: KAT6A, MYST3

Pathways: Stem Cell Maintenance, Embryonic Body Morphogenesis