NAT10 Protein
Quick Overview for NAT10 Protein (ABIN7939363)
Target
See all NAT10 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant NAT10 protein
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N-Acetyltransferase 10 (GCN5-Related) (NAT10) (AA 1-1025) protein (GST tag)
NAT10 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
N-Acetyltransferase 10 (GCN5-Related) (NAT10) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NAT10 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant NAT10 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))
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Alternative Name
- NAT10
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Background
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Protein Background: NAT10 (N-Acetyltransferase 10) is a RNA cytidine acetyltransferase that catalyzes the formation of N(4)- acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs and mediates the formation of ac4C at position 1842 in 18S rRNA. NAT10 requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, NAT10 is also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. It activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. NAT10 involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation.
Short Description: Recombinant NAT10 protein was expressed in baculovirus expression system as the full length protein (accession number NP_078938.3)) with a N-terminal FLAG tag. The molecular weight of the protein is 117 kDa.
Aliases: N-Acetyltransferase 10
Target
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