PPARA Protein
Quick Overview for PPARA Protein (ABIN7939411)
Target
See all PPARA ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant PPARa protein
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Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 1-468) protein (His tag)
custom-made PPARA Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 1-468) protein (His tag)custom-made PPARA Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 1-258) protein (GST tag)PPARA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 1-468) protein (His tag)PPARA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant PPARA protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))
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Alternative Name
- PPARa
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Background
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Protein Background: PPARA is a ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Short Description: Recombinant PPARA protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005027.2) with an N-terminal FLAG tag. The molecular weight of PPARA is 53.5 kDa
Aliases: Peroxisome Proliferator Activated Receptor Alpha, NR1C1, HPPAR, PPAR
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Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C
Target
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