PRDM16 Protein
Quick Overview for PRDM16 Protein (ABIN7939440)
Target
See all PRDM16 ProteinsProtein Type
Origin
Source
Application
-
-
Purpose
- Recombinant PRDM16 protein
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!ProductExpression SystemConjugateOriginPrice starts atExpression System Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin HumanPrice starts at $19,692.86Your project requires further customization? Contact us and discover our custom protein solutions
-
PR Domain Containing 16 (PRDM16) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)
PRDM16 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
PR Domain Containing 16 (PRDM16) (AA 19-471) protein (His-SUMO Tag)PRDM16 Origin: Saccharomyces cerevisiae Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
PR Domain Containing 16 (PRDM16) (AA 19-471) protein (His tag)PRDM16 Origin: Saccharomyces cerevisiae Host: Yeast Recombinant > 90 % SDS
-
-
Application Notes
- Optimal working dilution should be determined by the investigator.
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Buffer
- Recombinant PRDM16 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
-
Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
-
Storage
- -80 °C
-
Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
-
-
- PRDM16 (PR Domain Containing 16 (PRDM16))
-
Alternative Name
- PRDM16
-
Background
-
Protein Background: PRDM16 (Histone-lysine N-methyltransferase PRDM16), also known as CMD1LL, KMT8F, LVNC8, MEL1 and PFM13. PRDM16 was found in t(1,3)(p36,q21)-positive AML, which has similar clinicopathological features to3q21q26 syndrome, as a transcriptionally activated gene near the chromosomal breakpoint. The structure of the PRDM16 gene product is very similar to that of MDS1/EVI1. Both products have the PRdomain at the amino-terminus, 2 separated DNA binding domains with 7 and 3 tandem zinc finger repeats, CtBP-binding motifs, and other possible transcriptional regulatory domains. By similarity, PRDM16 probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation.
Short Description: Recombinant PRDM16 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_071397.3) with an N-terminal FLAG tag. The molecular weight of the protein is 141.5 kDa.
Aliases: Transcription Factor MEL1, KMT8F, Histone-Lysine N-methyltransferase PRDM16, CMD1LL, KMT8F, LVNC8, MEL1, PFM13
-
Pathways
- Stem Cell Maintenance, Brown Fat Cell Differentiation
Target
-
